New Zealand culture of intoxication: Local and global influences

This article shows that attitudes towards and behaviours involving the consumption of alcohol in New Zealand have long been problematic. It provides an historical account of social, economic and legislative factors which have influenced the development of the New Zealand drinking culture. Accordingly, it tracks a combination of local and global alcohol-related influences and documents the interrelationships amongst these factors. In particular, it proposes that the liberalisation of alcohol licensing laws and advertising/sponsorship regulations, alongside the growth of the alcohol-based hospitality industry have promoted the normalisation of an alcohol-based leisure lifestyle. Against this backdrop, the growth of consumer culture , tertiary student culture and the New Zealand drug culture, along with the development of new alcohol products and the establishment of commercial and social-networking websites have conjointly enabled the growth of a culture of intoxication, which is characterised by drinkers intentionally drinking to intoxication and viewing this behaviour as socially acceptable

Joy and calm: how an evolutionary functional model of affect regulation informs positive emotions in nature

Key theories of the human need for nature take an evolutionary perspective, and many of the mental well-being benefits of nature relate to positive affect. As affect has a physiological basis, it is important to consider these benefits alongside regulatory processes. However, research into nature and positive affect tends not to consider affect regulation and the neurophysiology of emotion. This brief systematic review and meta-analysis presents evidence to support the use of an existing evolutionary functional model of affect regulation (the three circle model of emotion) that provides a tripartite framework in which to consider the mental well-being benefits of nature and to guide nature-based well-being interventions. The model outlines drive, contentment and threat dimensions of affect regulation based on a review of the emotion regulation literature. The model has been used previously for understanding mental well-being, delivering successful mental health-care interventions and providing directions for future research. Finally, the three circle model is easily understood in the context of our everyday lives, providing an accessible physiological-based narrative to help explain the benefits of nature

Cyclic AMP modulation and its effects on chemo-resistant colon cancer cell proliferation and survival

One of the major problems associated with colorectal cancer is resistance to cytotoxic chemotherapeutic agents. New strategies are therefore required to inhibit colon cancer proliferation and survival. Here I use modulators of cAMP pathways, including inhibitors of phosphodiesterase 4 (PDE4) enzymes, which are under clinical development for other disease states, to inhibit the breakdown of cAMP and to assess the effects of raising intracellular cAMP on colon cancer proliferation and survival. I found that some chemo-resistant cancer cells are addicted to keeping low cAMP in PDE4 regulated compartments, and modulation of this pool causes G1/S-phase arrest and apoptosis. I also show that PDE4 controlled cAMP negatively regulates the PI 3-Kinase/Akt pathway, which some cells are addicted to for survival. Furthermore, I investigated the expression and role of PDE4 enzymes in metastatic colon cancer cells and assessed the effects of modulating their expression on survival. Also, I used a clinically relevant analogue of forskolin, an agonist of adenylyl cyclase, to examine the general effect on growth of epithelial cancer cell lines. This work might provide new strategies for the treatment of advanced colon cancer

Pleasure, profit and pain: Alcohol in New Zealand and the contemporary culture of intoxication

This book details the rich, complex and often contested role of alcohol in New Zealand society. It explores the three fundamental alcohol rights that continue to fight for dominance of the national drinking culture: the rights of individual drinkers to enjoy the pleasures of alcohol, the rights of society to protect itself from the harms of alcohol, and the rights of the alcohol industry to profit from the sale of a legal commodity. Historically, most of our intoxicated drinkers were adult males and drinking was typically separated from family, food and entertainment. With the sweeping social changes of the 1960s and 1970s, women and later young people, increasingly engaged with alcohol. A growing proportion of these groups have since joined men in a culture of intoxication, or binge drinking culture as it is often termed. New Zealand is not alone however, in having a culture of intoxication, with similar alcohol consumption patterns evident in many other developed nations. This book identifies the local and the global influences that have affected New Zealand society (and much of the rest of the world) since the late 1900s and details how these influences have sustained the contemporary culture of intoxication. Finally, this book will propose that to implement effective change to our national drinking culture, the rights of the alcohol industry and of individual drinkers will need to be pulled back from the liberal excesses that the 1980s and 1990s provided. A re-balancing is required in order to strengthen and sustain society’s right to protect itself from alcohol-related harm

Dual-functional materials via CCTP and selective orthogonal thiol-Michael addition/epoxide ring opening reactions

Poly(glycidyl methacrylate) (PGMA) has been synthesised by cobalt catalysed chain transfer polymerisation (CCTP) yielding, in one step, polymers with two points for post polymerisation functionalisation; the activated terminal vinyl bond and in chain epoxide groups. Epoxide ring-opening and a combination of thiol-Michael addition and epoxide ring-opening has been used for the post-functionalisation with amines and thiols to prepare a range of functional materials

Inter-Domain Integration of Services and Service Management

The evolution of the global telecommunications industry into an open services market presents developers of telecommunication service and management systems with many new challenges. Increased competition, complex service provision chains and integrated service offerings require effective techniques for the rapid integration of service and management systems over multiple organisational domains. These integration issues have been examined in the ACTS project Prospect by developing a working set of integrated, managed telecommunications services for a user trial. This paper presents the initial results of this work detailing the technologies and standards used, the architectural approach taken and the application of this approach to specific services

Experiences in Integrated Multi-Domain Service Management

Increased competition, complex service provision chains and integrated service offerings require effective techniques for the rapid integration of telecommunications services and management systems over multiple organisational domains. This paper presents some of the results of practical development work in this area, detailing the technologies and standards used, the architectural approach taken and the application of this approach to specific services. This work covers the integration of multimedia services, broadband networks, service management and network management, though the detailed examples given focus specifically on the integration of services and service management